A new paper by me – please share widely

26th August 2022

And so, after a great deal of faffing about, my article on cardiovascular disease ‘Assessing cardiovascular disease: looking beyond cholesterol’ has been made free to view.

Writing an article for a medical journal is not that difficult. Trying to submit it through Kafkaesque editorial systems, now, that is tricky. They seem incapable of understanding that I am not funded by anyone. Shock, horror, I do it simply for the love of science – or something of the sort.

As for allowing the article to be open access … don’t go there. I would rather fill in a US tax form, in triplicate and, yes, I have seen US tax forms in all their incomprehensible glory. I also spent considerable time trying to explain to the editorial team that the two risk calculators I discussed in the paper could not be referenced in the approved Vancouver style.

Vancouver style: required elements:

Author. Title [Type of medium]. Place of publication: Publisher; Date of publication [Date of update/revision; Date of citation]. Availability.

I could not use Vancouver style because there was no author, place or date of publication – to start with. They were both on-line tools used to assess cardiovascular risk. Helloooo… ever heard of the Internet. Thud!

Anyway, I was invited to write the article by Dr Eric Westman, who was the guest editor for this edition of ‘Current Opinion in Endocrinology, Diabetes and Obesity.’ In truth, I get about fifty invites a day to write articles. This is not a boast, anyone who has written almost anything that has been published in a medical journal is bombarded with such requests. New journals spring up like desert flowers after the rain.

Most of the requests are, essentially, vanity publishing. You spend ages putting together a paper that you then must pay to get published – you certainly have to pay a lot to allow open access. Usually thousands of dollars. The publisher meanwhile gains copyright. Then hardly anyone ever reads it. But, hey, you can send a copy to your mum – who will be very proud. If none the wiser what you are trying to say.

Thus, I do not respond to such requests normally. But in this case, I did. Eric Westman is a staunch ally in the crusade to look at different causal models of cardiovascular disease. Models not based on LDL/cholesterol levels.

For this edition he also invited others e.g., David Diamond to write other articles casting doubt on the LDL/cholesterol hypothesis – in the proper scientific manner. Dr Westman then paid to make them open access. A cost running into many thousands of dollars. Good man.

Anyway, here it is. https://journals.lww.com/co-endocrinology/Fulltext/9900/Assessing_cardiovascular_disease__looking_beyond.21.aspx

For those who have read my blog assiduously, or have read ‘The Clot Thickens’, none of this is new, or any surprise. However, I hope that it does add some more scientific credibility.  Here is the abstract.

Abstract

Purpose of review

The low-density lipoprotein (LDL)-cholesterol level is a weak predictor of developing cardiovascular (CV) disease and can only explain a small proportion of CV risk. It is not used to determine CV risk on either the atherosclerotic cardiovascular disease (ASCVD) calculator in the United States, or the Qrisk3 in the UK.

A study in JAMA in 2022 suggested that ‘the absolute benefits of statins are modest and may not be strongly mediated through the degree of LDL reduction’. Perhaps it is time to look beyond cholesterol to a different causal model – the ‘thrombogenic’ model of ASCVD.

Recent findings

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) pandemic demonstrated that infectious agents damage the endothelium and the glycocalyx – the glycoprotein layer protecting underlying endothelial cells. There are numerous other conditions leading to this kind of damage, which can trigger thrombus formation, causing strokes and myocardial infarctions.

Although these are acute events, they highlight a mechanism for the development of ASCVD which centres on endothelial damage and thrombus formation as both the primary causal mechanism for acute events, and the driver behind progression towards atherosclerotic plaque development.

Summary

The cholesterol hypothesis, that a raised LDL is directly causal for ASCVD, does not adequately explain cardiovascular risk in individuals, or populations. An alternative ‘thrombogenic’ hypothesis is proposed as a more valid causal model.

Here are the key points

KEY POINTS

  • Low-density lipoprotein (LDL)-cholesterol is a weak predictor of cardiovascular risk
  • Factors that drive endothelial damage and thrombus formation greatly increase atherosclerotic cardiovascular disease (ASCVD) risk.
  • The thrombogenic can explain a number of causal risk factors that do not fit within the LDL-cholesterol hypothesis, including type II diabetes, smoking and systemic lupus erythematosus.
  • The thrombogenic hypothesis, that endothelial damage and subsequent clot formation underlies the formation and growth of plaques, may represent a better model for ASCVD.
  • There is a need to research the thrombogenic hypothesis in more depth.

Stripping away the scientific obfuscation which is now required of all scientific writing. If anyone understands what you are trying to say, you lose. The two points that I was trying to make were the following:

  • The LDL/cholesterol hypothesis is most likely wrong. It is a weak predictor of risk, at best, and cannot explain how many factors known to increase the risk of cardiovascular disease, actually cause cardiovascular disease.
  • There is an alternative hypothesis, the ‘thrombogenic’ hypothesis which can explain how, and why, many different, apparently unconnected factors actually do cause cardiovascular disease.

I hope that the readers of this blog can make as much noise about it as possible and share it as widely as possible. You may even want to read the entire paper. It is not very long, and it is not too technical. At least I don’t think so.

Thank you.

119 thoughts on “A new paper by me – please share widely

  1. Robert Dyson

    Now I read what you wrote here. I have been an Eric Westman fan for some years. That he paid for open access just fits my image of him as a good and honest man.

    Reply
  2. Anna Gualandris

    THANK YOU Dr. Kendrick for helping blind folks to see the light within a dark tunnel of willful ignorance and pernicious deception.

    Reply
  3. Gary Ogden

    Thank you, Dr. Kendrick. Always good to revisit what we have learned and understand, and trust to be most likely true, about the process of CVD development. Clotting system gone awry.

    Reply
  4. dearieme

    Congrats, Dr K.

    Years ago I read a piece on the rise and fall of heart attacks in middle-aged men. The writer said that the curve looked all the world as if it described an infectious disease. Now the Blessed Malcom says “infectious agents damage the endothelium …”. Maybe those heart attacks were indeed (mainly) the result of an infectious agent; if so it would be handy to identify the pathogen.

    Which leaves present day heart attacks which are (correct me if I’m wrong) mainly just another way for old folk, of either sex, to die. What causes them?

    P.S. I will now advance my own conjecture about why the male, middle-aged heart attack rate plummeted. It was all the antibiotics that GPs handed out “like sweeties” to the scorn of right-thinking people everywhere. In which case our pathogen would be bacterial I assume. And those GPs would have extended many lives.

    Reply
      1. Herb

        Lots of research focusing on the Endo thelium suggests that it does but there’s no studies I’m aware of the product’s impact on cardiovascular events or mortality.

        Their website has a comprehensive analysis of all of the research that’s been conducted on the product

        Reply
  5. Tom

    Always good to see ideas apart from the standard medical nonsense. Thanks. I am finding non-drug treatments using herbs and supplements to be working well with no side effects for my heart troubles.

    Reply
  6. Tom

    Always good to see ideas apart from the standard medical nonsense. Thanks. I am finding non-drug treatments using herbs and supplements to be working well with no side effects for my heart troubles.

    Reply
  7. John C

    WRT referencing websites, from University of Bath website
    “ Author(s)/Organisation. Title of webpage [Internet]. Place of publication: Publisher; Year of original publication OR Year of Copyright [updated year month day; cited year month day]. Available from: URL.”
    “ National Institute for Health and Care Excellence. Antiplatelet treatment: management [Internet]. London: NICE; c2018 [updated 2018 Jun; cited 2018 Sep 28]. Available from: https://cks.nice.org.uk/antiplatelet-treatment.”

    Reply
  8. JohnC

    Could another factor be the presence of PF4 antibodies which cause platelets to become sticky and can happen in some people after heparin injection or the AstraZeneca Covid vaccine?

    Reply
  9. Frederica Huxley

    Alas, this is what you are up against – article in The Times today “Elderly urged to take statins for life or risk losing health benefits“, repeating all the usual propaganda about statins and the cholesterol hypothesis.

    Reply
    1. Prudence Kitten

      I wonder what those “health benefits” can be. At the moment my idea of a “health benefit” is keeping as far away as possible from doctors and hospitals. (Dr Kendrick and a select few others excluded, of course).

      Reply
  10. David Vicknair

    Been reading The Clot Thickens in fits and spurts. About 1/3 through. Your self effacing writing style frequently brings forth smiles in what might otherwise be a rather obtuse read for this academic accountant. I sincerely hope you live long enough to deliver a well deserved “I told you so!” to the broken records (scratch… take your statin… scratch… take your statin) who are our physicians.

    Reply
    1. Prudence Kitten

      As well as a fine doctor and a magnificent research scientist, I think Dr Kendrick may be an example of that fast-vanishing species – the gentleman.

      Reply
  11. Mark Philbin

    For a moment I thought today’s blog was going to be in response to today’s article in The Times quoting new research suggesting we should be taking stains – for life!

    Reply
  12. james

    Thanks Doctor Kendrick, will try and share as much as possible, it’s the least the rest of us can do, considering all the work you do in the face of hostile, entrenched, dogma.

    Reply
  13. Jonathan Christie

    Good one, well done!

    The 3rd bullet point under “KEY POINTS” says: “The thrombogenic can explain a number of causal risk factors …” – I think ‘hypothesis’ is missing

    Reply
  14. Tish

    Worth a celebration because much of it should have been written at least 50 years ago. People have suffered. Good on you.

    Reply
  15. Peter Ford

    Congratulations, Malcolm, on getting published, open access to boot. (I too get bombarded with offers to publish me – for a price, no doubt – in specialist medical journals even though I am not a medical expert and only got published in The Lancet because I wrote about the ghastly impact of sanctions on Syria on medical outcomes for ordinary Syrians.) Let us hope that just as the covid con is beginning to crumble so will the cholesterol con..

    Reply
  16. Ruth Baills

    If anyone understands what you are trying to say, you lose. 😂😂😂😂😂😂😂😂😂. Love your sense of humour. Thank you for all your hard work to make sense in this crazy world we find ourselves in.

    Reply
  17. Dianne Fraser

    I really appreciate your insights and clear information. Thank you! I always look forward to receiving your emails and the pearls of wisdom they contain.

    Reply
  18. Eggs ‘n beer

    “Here goes Kendrick again on his anti-statin crusade. Will he never give it up? Now he’s using a 170 year excuse of a theory to pretend that there’s an alternative possibility to cholesterol causing blockages! Who will rid us of this turbulent Scot?”

    P. Harma B.$¢.

    A neat, concise but dry explanation. Heaven forbid that humour, that great teacher, should be allowed in scholarly articles. Although Matthew Mold did seem to be verging on Young Frankenstein (Marty Feldman) when he was talking about the difficulties of obtaining healthy brains in his series of papers on aluminium in brains of autistic and demented patients.

    Reply
    1. Steve

      I’ve yet to meet a single person taking statins who hasn’t complained about the side effects: tiredness, aches and pains, foggy head, …
      Most of them seem to either take themselves off the statins or reduce the dosage – and immediately feel much better and ‘normal’ again.
      Why do the medical profession keep dishing out this rubbish ? – ignoring the obvious factors of financial benefits and culling of the aged.

      Reply
  19. jeresavo1

    I can see the marketing people examining what might possibly restrict sales of their sponsors magic pill and a number of doctors, among others will be identified as having a negative effect on sales- whether its 10% or 40% a strategy will b developed & evaluated to reduce that effect by whatever % – and it wont be above board – as usual instead of improving the product etc it will be about devaluing the messenger & the message. I hav no doubt. I believe the marketing business is very nasty- results matter – at any cost. Money being the essential factor.

    Reply
  20. Jennifer

    Congratulations!!! You deserve all credit for your sincerity, determination and generosity in getting such important issues out to the public.
    I am trusting that you are coping with your personal situation, towards a bright future.

    Reply
  21. Martin

    So I lie in bed reading the start of chapter seven ( I’m on page 197, since you ask) of your latest book The Clot Thickens. I then decide to take a quick check to see if you’ve added another blog entry. Imagine my surprise when the blog entry deals with exactly the bit of the book I’ve just got round to reading. Spooky!

    Although there are still nine more chapters to go, I intend rereading as soon as I finish and putting markers in the book as I go along, so that I can construct how my cardiovascular disease has indeed been caused by various factors in my life.
    As I’ve been reading through the book I keep remarking to myself…”Yes that’s spot on”. So you see, it’s been quite a revelation to me, a non-medical man whose only interest stems from a steadfast refusal to take statins…suddenly, an awful lot becomes quite clear. I intend gifting your book with all the markers and my comments to my young GP (6/7 years post qualification) who I really rather like, but who still tries to persuade me to take statins as I am apparently ‘under medicated’

    I say I’m a non-medical man, but to date, I have had five MIs (last one on 24th June) the first was way back ten years ago (29.4.2012) aged 53yrs when they inserted two stents and failed with a third.
    By the law of averages I don’t think I’m supposed to be alive, certainly when they discharged me from hospital after MI no.4 (September 2021) the hospital issued me with a bottle of oramorph and in effect wished me good luck.
    My arteries are too damaged for further stents and they can’t Bypass…as apparently you have to have some good arteries available to be able to do this!

    So at 23:00 on 24th of June (MI no5…pay attention at the back) I sat in my lounge taking oramorph and willing the pain away, which it eventually did two hours and fifty minutes later. I didn’t call the paramedics as I have a DNR in place and the hospital had previously made it clear that there were no interventions that they could carry out. It seemed a bit pointless therefore, going into hospital. On the plus side, for the first time in ten years I was able to get morphine down my throat almost straight away. In all my four previous MIs the paramedics have been unable to get a line into my veins to give me pain relief when travelling en route to hospital.

    I rang my GP four days later to ask for some replacement morphine, as I had spilt some in my haste to get it into my system and I mentioned to him that I thought there was a 95% chance I had had another MI. A suggested visit to the Ambulatory Ward for some blood tests and ecg showed troponin of 500+ (Four days after the event)
    My all time record was MI no.2 (on 5.10.2014) which was 14,414. I was assured that had I called the paramedics it would of course have been higher than the 500+

    With ten minute appointments, there is obviously not enough time for a GP to know a patient’s life history. All my GPs know from looking at my record that I took early retirement from teaching, aged 43 due to hearing loss. None of them knew what happened in my successful teaching career at that point, that made it a great idea to seek early retirement on ill-health grounds.

    My point is, that having read so far in your book, The Clot Thickens, I have been piecing together so many factors you have written about, that in my opinion have confirmed in my mind some of the causes of my cardiovascular problems.

    Sorry to have gone a little bit astray from your blog article but you need to know, from someone who has had quite a bit of trouble in the old arteries department, that your blogs, books and YouTube videos have been inspiring despite the battles I’ve had with various GPs and Consultants who will only travel the Statins route.

    I’ll also pass on the ‘paper’ to the GP so you get some more academic credibility!

    I also hope your prostate treatment is going well…your knowledge and wisdom is required even more in these times of ‘following The Science’

    Reply
      1. Martin

        I have had hearing loss since the age of six around the time I had measles. I always just assumed some people mumbled.
        My adult hearing was only measured since 1989 at my request. It has not deteriorated much since then.

        I have high pitch hearing loss in both ears. If you are not a medical person try saying: “ The cat sat on the mat” without pronouncing the consonants. That is how I hear without my hearing aids. Those consonant sounds are crucial to making sense of the spoken word!

        The two Ronnies did a great sketch which also played on how sound is misinterpreted: The scene in set at a party. Barker greets Corbett by remarking: “Tickle your arse with a feather”
        Affronted, Corbett responds by slapping Barker in the face and making it clear he is offended.
        A stunned Barker replies: I only said: “particularly nasty weather”

        Most people hear the sounds between 125 – 8000 hertz of a hearing test, needing no more than up to 20 decibels.

        At the low end of the range (low sounds) to hear 250 Hz I need a minimum 40 decibels (20 decibels more than a person with normal hearing) and it gets worse the higher the hertz.
        At 8000 Hz I require 100 decibels (80 more decibels than the normal hearing person) in my left ear and 110 decibels in my right (90 decibels more)

        Several audiologists had remarked that it was amazing that I had lasted so long in teaching with that level of hearing loss.

        Hearing aids are not perfect, they do not restore perfect hearing. Some of the foreign doctors and nurses in hospitals are a case in point. I find certain accents quite difficult to decipher. Indians in particular, tend to put the accent on different syllables in a word and my brain scrabbles around trying to make sense of the sound my hearing aids provide. I always have to explain this to them.

        I hope that answers your question. But I could have used my hearing loss to get out of teaching at any point and not waited until 21 years had passed.
        I used the hearing loss ticket when it was convenient for me after a traumatic non medical event, which I am certain from reading ‘The Clot Thickens’ was a significant contributory factor affecting my later arteriosclerosis and subsequent MIs

        It’s not all bad….it is a most wonderful sensation to be able to remove my hearing aids at the end of the day and enter the most peaceful world…knowing that even storms are unlikely to wake me!

        If you’re a medical person…apologies for the mansplaining!!

        Reply
        1. Dr. Malcolm Kendrick Post author

          I think that the stories people tell about their health issues are incredibly important. Far more memorable, and place dry scientific facts within the context of real life. They are also far easier to remember.

          Reply
        2. Philip Mulholland

          Martin,
          I too have high frequency hearing loss and experience real problems with consonants particularly on the telephone. The biggest challenge however is with names, if the name is novel to me then my chances of being able too hear it are low. This is an example of pattern recognition and word order context that is critical to communication. In this situation I always have to ask for the name to be spelled out for me.

          Reply
          1. JDPatten

            Martin and Phillip,

            I was seven years old when measles and an opportunistic infection ruptured my right eardrum and detached it from the “hammer”. Needless to say, I was at a disadvantage in what was likely my most formative years.
            Pop songs had lyrics? The effort needed was not worth understanding 1950s and 1960s lyrics anyway, right?
            My theory: During those formative years I missed a great deal without knowing because I had trained my brain to ignore anything beyond the very easily understood. How much had I missed? How had that hearing loss effected me as a developing member of society?
            I think that what my brain does now is to ignore logic and just go with the most simplistic interpretation.
            How many of the normal hearing public would go with the improbable “tickle your arse with a feather” spoken softly, when the more logical comment is fairly obvious? I never learned that skill. Not even after I had the eardrum fixed 12 years ago.

    1. Corinna Lennox-Kerr

      Martin,

      Thank you for sharing your story with us.

      We are lucky indeed to have the Great Doctor spending so much time and energy as well as knowledge, wisdom and humour in his writings and that he is passing on his well-researched work to all of us so that we can share it with others.

      I hope you remain with us for a lot longer Martin and it’s good knowing that you are literally taking your own life in your hands and not being bullied into doing what the GPs feel is the best for you and which we all know is so wrong!

      Corinna

      Reply
  22. Anna

    Much enjoyed your intelligent analysis. Many thanks,and deep respect to your bravery in this crazy world. You have greatly helped me organise and understand my health and the health of my kids. I will be making noise about the article indeed.

    Reply
  23. Mark Heneghan

    I much prefer this hypothesis to the ldl one. It also shows how type 2 diabetes, which has 11 times the risk (that’s 1000%) of CVD relative to non diabetics, in one study, is so important. It also explains why losing weight and reversing diabetes with a low carbohydrate diet is much more likely to be beneficial than following a calorie restricted low fat high carbohydrate diet that is still being advised.

    Reply
  24. Dana

    I generally follow a low-carb eating style as set out by Dr Eades and his wife in his book. When I have blood checked, the LDL (so-called bad) the GP always pressures me to take statins. Only recently have I viewed a youtube with Dr. Nadir Ali – ‘Why LDL cholesterol goes up with low carb diet and is it bad for health?’ and read a comment by Dr Eades in his newsletter under the heading :Lean Mass Hyper-responders.

    Reply
    1. jeresavo1

      Thank you
      One to listen to a few times. At 2 minutes though, he refers to LDL as a very important “molecule”. Its not a molecule – am I not right in thinking ?
      It gets really interesting after 11 minutes with the results of long term studies.

      Reply
  25. thecovidpilot

    Going off on a tangent about another paper out of UK, including Oxford, Leicester, Edinburgh…

    Title: “Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex ”

    From the paper’s methods section: “The incidence rate ratio and excess number of hospital admissions or deaths from myocarditis per million people were estimated for the 1 to 28 days after sequential doses of adenovirus (ChAdOx1) or mRNA-based (BNT162b2, mRNA-1273) vaccines, or after a positive SARS-CoV-2 test. ”

    https://pubmed.ncbi.nlm.nih.gov/35993236/

    The paper’s approach works if vaccine and covid infection are exclusive, with no overlap. But if there is overlap, you have logic problems…

    By now we know that covid vaccination is non-sterilizing, so we are certain that there are individuals in both the injected and the covid-infected groups.

    Here’s an example to demonstrate the problem with the paper’s logic:

    Let’s suppose that we have 6 vaccinated who get myocarditis after covid. Let’s suppose that we have 4 unvaccinated who get myocarditis after covid. So there are 10 total who get myocarditis from covid.

    The harm value for vaccinated is therefore 6/10, or 0.6, which seems to be a benefit.

    The harm value for the unvaccinated is 4/10, or 0.4, which is an even greater benefit.

    How can both be a benefit? They can’t. The problem stems from the fact that you have some of the same people in both the vaccinated and the covid-infected group
    who get myocarditis.

    The true harm value for the vaccinated comes from comparing the vaccinated with the unvaccinated– 6/4 –1.5, which means that vaccination causes increased risk of myocarditis over being unvaccinated.

    Clare Craig wrote an article published in Daily Sceptic about this very point.

    I sent an email to the author with this question and will be curious how she replies.

    I would be embarrassed to have my name on this paper. 🤣🤣🤣

    Reply
  26. Patrick Donnelly

    Immune system is designed to protect the appropriate DNA. It is prepared to kill an individual to save the entire species or phylum etc. It does this by clotting.

    Save yourself and deserving people by taking nattokinase or serrapeptase. These are enzymes that help the body reduce proteins to amino acids, with scrap from clots and scars going to the lungs to be coughed up as phlegm.

    Reply
  27. Laurence May

    Solving the Mysteries of Heart Disease: Life-Saving Answers Ignored By The Medical Establishment Paperback – June 17, 2018
    by Gerald D Buckberg MD (Author)

    A world-renowned cardiac surgeon and researcher reveals proven treatments for heart diseases – are not being used by the medical community.

    Solving the Mysteries of Heart Disease describes the passionate lifelong journey of Dr. Gerald Buckberg, whose early discoveries have already helped save the lives of 25,000,000 heart disease patients. Yet Buckberg and his teams have pioneered additional advances that may save millions more – advances that are being ignored by the medical establishment.

    These include breakthroughs that reverse congestive heart failure, treat sudden death/cardiac arrest with 80% survival (compared to the current rate of 15%), avoid heart muscle damage after an acute heart attack (that can lead to heart failure), and significantly improve effectiveness of pacemakers. Few families are untouched by one of these or the other conditions described in this book.

    A Distinguished Professor of Surgery at the David Geffen School of Medicine at UCLA, Dr. Buckberg’s initial landmark research dramatically transformed high-risk open heart operations into the routine procedures they are today. Over 85% of cardiac surgeons in the United States use his techniques. So why haven’t his team’s subsequent groundbreaking discoveries yet been adopted as standard practice?

    The personal story of a relentless quest to solve problems long thought insurmountable, Solving the Mysteries of Heart Disease tells of triumphs over formidable odds and initial failures. It provides a deep understanding of how the heart works and what happens when things go wrong. At the same time, Buckberg exposes why the medical field has been too slow to adopt treatments proven effective in patients in the U.S. and internationally – remedies that could create a revolution in healthcare.

    Reply
  28. Steve

    Excellent Paper, let’s hope it gains some traction within the medical profession.

    Another paper that may be of interest to commentators:
    ‘Self-Selected COVID-19 “Unvaccinated” Cohort Reports Favorable Health Outcomes and Unjustified Discrimination in Global Survey’, [1].
    BTW, I found this paper via the ‘The Daily Sceptic’, [2].
    [1] https://www.ijvtpr.com/index.php/IJVTPR/article/view/43/78
    [2] https://dailysceptic.org/2022/08/31/international-survey-of-unvaccinated-control-group-reports-its-findings/

    Reply
  29. Eggs ‘n beer

    Thank you so much for that link, Steve. I joined the Control Group mostly out of a desire to play havoc with ’the system’ by flashing my ‘must not be vaccinated’ card at the authoritarian morons eagerly applying the narrative to all and sundry, and did indeed have some fun with it. Although the ‘I am exempt from wearing a mask’ phrase seemed to generate the most ire. And Lo! It came to pass that my unworthy suspicions that the CG might not have any intention of carrying out actual research proved unfounded. Now I have a peer reviewed paper to thrust under the noses of the doubters, who have no idea how little peer reviews mean but hey, it’s what they insist upon. Thanks again.

    And, shock-horror-probe, it reveals that non-mask wearers were least likely to contract covid.

    At this point it is becoming difficult to suppress my pride at steering (most of) my family and many friends through this fiasco by encouraging not wearing masks, not vaccinating, giving up your job, vitamin D, not hand washing and going about your life as much as normal to ensure you ARE exposed to the virus, and any other bugs going around, to keep your immune system on its toes. But I’m an engineer, and an accountant, and doing a manic jig with the study down at the shopping centre in front of the 20% of ignoramuses still wearing masks just isn’t in my character.

    Reply
  30. Charles Gale

    Arterosil/glycocalyx

    Further to Herb’s comment dated 26 August concerning his use of Arterosil for his glycocalyx, there is another product for the glycocalyx from Microvascular Health Solutions called Endocalyx Pro. Here’s a link to their site which I think is worth a browse:

    https://microvascular.com/endocalyx-anti-aging-supplement/

    What I found exciting was that the glycocalyx can be tested. Sadly, not here in the UK.

    Ticking off a few of their organ starvation criteria it is tempting to try their product.

    But put off by:

    (1) Lack of testing in UK. If nothing else, I’d like a before and after test to monitor any progress in the condition of my glycocalyx. Their product is outside my budget at the moment to start buying without some starting point and

    (2) With a 7 year old CAC score of 1500 I don’t think my glycocalyx is in good condition, if there is any left at all. I bet it doesn’t regrow over all the damage.

    Herb, did you get a test?

    Reply
    1. JDPatten

      Charles,
      Are you a sportsy guy? Worked at a physically demanding job?
      There is a research article out there – somewhere – that seems to indicate life long competitive athletes and others who chronically over-exercise have way high CAC. Stands to reason, I guess. What they don’t give a reason for is why that does not seem to result in heart disease symptoms in those people.
      My own CAC from 10 years was 1,640. Weight training in my youth? Hard work on the farm?? Cutting all my own firewood… after building my own masonry fireplace with 2 flues 40 feet high???
      (Sorry, the research was a few years ago and beyond my memory of where.)

      Reply
        1. An Italian Australian at the Tropics

          Another correlation and not causation BS study.

          It could be the diet (likely), the vitamin D levels, global warming or fluoride in the water, for what we know.

          As a nutritionist working with elite athletes, I can attest to the fact that they aren’t as healthy as most people think.

          Reply
          1. Martin Back

            An elite athlete commented that if he wasn’t getting colds and flu, he knew he wasn’t training hard enough. He blamed his immune system.

            I wonder if it’s maybe because athletes do a lot of strenuous activity which leads to them breathing deeply for an extended time, so they get a much bigger volume of potentially infected air into their lungs compared to non-athletes. At a guess it’s ten times or more exposure to air-borne infectious agents, and they will be sucked deeper into the lungs.

          2. An Italian Australian at the Tropics

            It’s just stress, combined with constantly elevated insulin levels (even when insulin shots aren’t used; yes, it’s doping, but you can’t detect it, so). Athletes eat large amount of carbs and sugars, they seem not to have issue with that diet because they are lean, but the metabolic damage is the same as obese people.

          3. Eggs ‘n beer

            And why should they be? Why there should be any correlation between muscle fitness and the rest of the system has always seemed an illogical assumption. Fit people still drop dead from strokes and heart attacks, catch cancer, the ‘flu, suffer nerve diseases etc. etc. And Churchill died at 91. Just imagine how long he’d’ve lived if he had even moderately exercised regularly.

          4. Sasha

            Muscle fitness has huge correlation with overall fitness of the system. The evidence for it is quite large, as far as I know. The key is not to overtrain.

          5. Gary Ogden

            Sasha: Thanks. Two very good points. In attempting to reverse my age-related loss of muscle mass, I’ve discovered it is not enough merely to use them, but essential to increase high-quality protein intake. I’ve upped my beef intake to 1.5 lbs. per day, which contains 150 g complete protein (a bit more than 1g/lb. of body weight), along with 2.5 g potassium.

          6. barovsky

            Gary,
            1.5 pounds of meat a day?!! Aren’t you sick? How’s your digestion? Frankly, the idea of eating 1.5lbs a day of red meat sounds disgusting!

          7. Gary Ogden

            barovsky: I feel better than I have in years. Meat (including organs) is the most nutrient-dense food available. The key is ditching vegetables. Plants, especially their leaves, are full of nasty, self-defense chemicals. In addition to beef, I eat eggs, raw dairy, occasional seafood, fruit, and honey. I began eating this way due to Dr. Paul Saladino’s book, “The Carnivore Code.” I’ve (mostly) always slept well, but now I fall asleep, like Napoleon, within minutes of turning out the light. One of the best changes I’ve made. I feel like I haven’t any inflammation any more. Peaceful, calm, energetic. Dr. Kendrick’s books have been a great help on this score, too.

          8. An Italian Australian at the Tropics

            Not for most human beings.

            I eat 1.5 pounds of red meat plus 8 eggs a day on average, never been better.

          9. Gary Ogden

            An Italian Australian in the Tropics: Good for you. For me this has been the way to health. And delicious! The digestive system works like a champ. As Dr. Kendrick correctly stated in one of the books, the fruit and vegetable diet was “made up out of thin air.”

          10. An Italian Australian at the Tropics

            I have to admit that I like vegetables, especially the fresh ones from the local farmer’s market, but I have to be careful and I can’t eat them at night or I won’t sleep because of stomach issues, even if I have the last meal at 5pm.

            After several years on this diet, even my 52 kg wife is now eating easily a 300g steak for lunch, even if she used to be a real pasta lover and used to eat very little meat. At 59, she deadlifts impressive weights compared to her bodyweight.

          11. Gary Ogden

            An Italian Australian in the Tropics: I must say, after 2 1/2 years eating this way, I don’t miss vegetables. I used to grow and eat lots lots of them, but now am down to only garlic (and ornamentals) because it is fun to grow and keeps a long time. Bit of a naughty pleasure. This diet has given me remarkable physical health and mental health, too. While deeply concerned about what this 2 1/2 year psy-op has done to nearly everyone, I don’t get mad about it, or anything else. My response is to treat everyone (except the politicians) with kindness and generosity and good cheer, and to find joy in living each day. This is an extraordinarily valuable gift given me by meat, and meat alone. Perhaps this is why the thugs who run the world want us to stop eating it?

          12. An Italian Australian at the Tropics

            I’m a bit of a gourmand, that’s all. Garlic and chilli I still use (of course, look at my alias!), plus coffee and wine which constitute the bulk of the vegetables I eat, and the occasional treat of a 90/100% square of chocolate.

            I plan to have a veggie garden in my new house, though, mostly to feed the chooks and do some food swap.

            I agree about not only the physical health achieved with this diet, but also the mental clarity and calmness. I used to be a bit of a dick in my past, with a (very) short fuse. Now my wife always tell me how different I am when confronting people, not sure yet if she’s pleased by the change… 🙂

          13. Eggs ‘n beer

            Any links for that? Why would muscle fitness give better immunity to Covid, for example? That seems to depend on T cells and vitamin D levels. I see no correlation there for covid. Two very fit sons, one has had it twice, one never. Four of us oldies (57-91yrs) haven’t caught it either. Only one of the 91y/o is jabbed. The oldies are taking D.

          14. thecovidpilot

            Gary,

            Are you on a mostly carnivore diet? Any eggs? Do you mix in some pork on occasion or fish?

            Any problems with gout?

            Kelly Hogan’s vids about her carnivore diet are interesting.

          15. Gary Ogden

            thecovidpilot: Yes, mostly carnivore. I discovered that I needed to add back some carbohydrates, so I eat some fruit and honey. Two eggs each day. Occasional salmon, but when what I have in the freezer is gone, I won’t be buying any more, due to concerns about ocean pollution. It is my understanding that ruminants are best. High-quality, grass-fed and -finished beef is easily available here, so beef it is. We have a raw-milk dairy here, whose cows are on pasture, so I eat kefir, butter, and cheese. I like pork (especially bacon!), but good-quality pork is hard to get (I buy all my meat directly from farmers), so I don’t eat it very often.

          16. An Italian Australian at the Tropics

            I buy some raw milk from a dairy on the Sunshine Coast or thereabouts, sold as “bath milk” because of the stupid laws, but luckily not as stupid as in Victoria where they have to add a bittering agent to it.

          17. An Italian Australian at the Tropics

            I’m on a keto carnivore diet, basically a ketogenic diet with high protein and very little, selected vegetables.

            Plenty of eggs (often 8 or 12 for dinner), some pork (I love it and I also make my own smallgood, bit I try to keep PUFAs at a minimum), fish a couple times a week, mostly loval wild caught.

            I started low carb 15 years ago, than quickly moved to keto that suits me better.

            Gout? Is there really any evidence that meat causes gout? I haven’t seen any. If meat was responsible, wouldn’t bodybuilders have big issues with gout? Most of them are on 3 g or more of protein per kg of body weight per day, and yet no gout.

          18. Frederica Huxley

            Purines are the cause, and they are to be found in such disparate foods as salmon, strawberries, cucumber, peas and beer! I learnt this 30 years ago when my ex succumbed to gout.

          19. jeresavo1

            Got speaking to a youngish man who lost his mother at 62 yrs of age after hospital treatment (not vax) and who now refers to the tragic event as murder by the hospital authorities. But in his pursuit of “the truth” & following his research he now believes that coffee (caffeine element), dairy products and meat are to be avoided and all water is contaminated especially well water due to such as roundup & other chemicals. He seems like an alert & reasonable sort and will quote many studies including one by stephen cherniske with the dramatic title “caffeine – wake up to the dangers of Americas no 1 drug.” and a better known study apparently
            https://switch4good.org/largest-comprehensive-study-of-nutrition-links-dairy-and-disease/
            In the wet fringes of western europe dairy has been a mainstay possibly for millennia as is meat. He also contraducts himself to some extent by saying that meat can only be eaten raw. Caffeine is a newer intro to these parts – allegations being made that it reduces blood flow to the brain while the traditional Tea break was designed to placate / seduce workers in to a sort of sedation.
            Anyway, I got a headache trying to tease all this new scary stuff out.

          20. An Italian Australian at the Tropics

            Out of curiosity, I opened the link you provided.

            It starts praising the China Study.

            Oh, dear…

          21. jeresavo1

            Tell me more. The study was carried out by american colin campbell. The allegation made is that only those who switched to dairy in this china based study developed cancer. You sound sceptical which is great. I would love to know the grounds for your scepticism. I too am sceptical as I thought I had made clear in my post. The other allegation made is that campbell was somehow prevented from carrying out the study in the US. Is the study flawed ?

          22. An Italian Australian at the Tropics

            There are so many published papers and detailed analysis of that study that you have plenty of choice if you are so inclined.

            To me, I don’t believe in the “he misinterpreted the data”, the whole study was a fraud from the beginning and the analysis of his own data is so ridiculous that it is the subject of jokes about correlation and causation.

            Also, the cholesterol myth, vegans really like the cholesterol myth. But of course he needed the cholesterol myth as a third agent, because in the data there is no correlation at all between animal protein and cancer.

  31. Prudence Kitten

    Please forgive my dropping this link here – I think it’s the most likely place for it to be noticed. Apologies if anyone has already drawn attention to it.

    As an unqualified layman I found it impressive and worrying.

    https://jessicar.substack.com/p/is-the-spike-protein-acting-as-a

    “Is the spike protein acting as a prion with regard to hemoglobin molecules? And is porphyria being induced?”
    “If the answers are ‘yes’, this is very bad news”.

    “So the bottom line of all of this information is this: the virus infects the RBCs using spike protein via the CD147 receptor on red blood cells which causes hemolysis (rupture of the red blood cell). This causes the release of massive amounts of hemoglobin. Then the spike protein, due to its amyloidogenic peptides, triggers mis-folding of the hemoglobin into amyloid fibrils causing subsequent blood clots. The blood clots would be enhanced due to antibodies (Ag:Ab complexes). So a big remaining question that needs to be answered is: Under what circumstances can and does hemolysis occur in the context of the COVID-19 injections due to the spike protein?”

    Reply
  32. Steve Garrett

    Please allow me to thank you for all you have taught me the past few years. Having three CAC’s with calcium scores from 1200-1500 put me in full research mode. Four cardiologists said ” you must take a high dose statin and eat a no fat diet”. You know how that went. After reading your books and blogs, as well as a few others by folks who reason like you, I am on a very low dose statin and a high fat, low carb diet. Forgive me for the low dose statin but I am convinced it just might lower CV inflammation without messing around with my LDL and HDL in a bad way. Anyway, thank you for being a voice of honest reason, and by all means please keep up the detective work and publishing.

    Reply
    1. Janice Willoughby

      september 6, 2022
      Since you are in research mode, Steve, I wish to recommend a visit to Tucker Goodrich’s Yelling Stop blogsite. He currently features recordings of discussions with Dr. Brenna, medical researcher, focused on Omega 3 and Omega 6 lipids and their impacts on health. I have only started listening, and there seems to be a lot of information there.

      I hope your journey of healing goes well.

      Reply
  33. thecovidpilot

    Off topic, but needs sharing…

    “On Wednesday, August 31, the FDA issued emergency use authorizations for new Pfizer and Moderna mRNA booster vaccines for COVID. The next day, September 1, the CDC’s advisory committee and CDC Director approved the immediate rollout of the new vaccines. They will be administered in the US starting this week.

    Surprisingly, more than a month before either agency had given its okay to the entirely new formulation, the federal government ordered 105 million doses from Pfizer and 66 million doses from Moderna.”

    https://merylnass.substack.com/p/the-high-speed-bivalent-covid-boosters

    The elites have abandoned any pretense that the FDA is a regulatory agency.

    Please send the Nass article to your lists and note the irrelevance of the FDA.

    Don’t forget to subscribe to Nass’s substack.

    Reply
      1. Gary Ogden

        tonyp: The Mafia dons who run things in the U.S. have dropped all pretense of using evidence to drive policy in the medical realm. Good book coming out on September 22: “One Nation Under Blackmail,” by Whitney Webb.

        Reply
  34. Nina

    I am in the process of reading your book, The Clot Thickens, difficult to put it down. It is wonderful & I wish I knew this when working in ICU & Coronary Care units during my nursing career. I’ll be looking for everything you write. Incredible information & your sense of humor is delightful! Thank you.
    Nina

    Reply
  35. Daniel R

    I am new to this blog and just found out about Dr Kendrick via recommendation from another doc. Currently on statin medication and would definitely like to stop taking them, since no other risks (low triglycerides, high HDL, no diabetes) except family history (my oldest brother had bypass). The decision to start taking statins was after getting a CAC score, which was about 50, showing proof of (mild) cardiovascular disease. If my only biomarker is high LDL, and there is arterial damage – why would there not be an association, what else could be causing it?

    Thank you, appreciate this educational blog and helpful comments.
    Daniel

    Reply
  36. JDPatten

    Lupus!
    One of the worst culprits in the exacerbation of Cardio Vascular Disease!
    Fixed?
    Maybe.
    Mess with B cells and… cured? It SEEMS so.
    Further research needed – as usual.
    https://www.nature.com/articles/s41591-022-02017-5.epdf?sharing_token=jsWCAV_syKNUKDgYd78YXNRgN0jAjWel9jnR3ZoTv0P6POblByiHambqf6w0I3bDRugkw3VvD2dRSHrkOb2krjKMkpvjaw71jjiH_zDBXvlCYmoc6fP_gyd0fV7ulP-6VAcwEsv-eAcxdyTUWeCucLJArwuAAGAoDVIu7aBaM-AJnDzLj0bq-H64Psft9FI0z9wXWwINpNyUdsNH7i5UBGjJoFFqZ7M1LPhkkvE40bOYZHgXG2e2Ga_O_IadTBPURbJo-kccG9CloE4VZocRPnAs9eP8td0uSDdWXWYvmYoiky3rlq4BmbRyUpJG5v36FeeHB8_4jzVI2tWfhqdl96R26e0jK9POowxamcMgHo4%3D&tracking_referrer=www.theguardian.com

    Reply
  37. Jerome savage

    Two outcomes during the early stages provided a good case for skin colour as a causal factor- as I recall. Might not have completely accurate percentages but they are not, so to speak – a away miles away –
    First I recall references to how the BAME folk in the UK hospitals were adversely affected by whatever was out there, they accounting for 40% of the workforce yet accounting for 90% of hospital admissions. (BAME being black Asian & middle Eastern )

    In Malmo, Sweden the somali – Ethiopian population accounted for 5% of the population while taking up 40% of the króna hospital beds.

    Reply

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